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St. Luke’s Medical Center takes pride in its international affiliation with Weill Cornell Medical College of Cornell University. It is an affiliation that enhances St. Luke’s commitment to quality of care and secures the Philippine hospital’s position as the benchmark of superior healthcare not only locally but in the Asia-Pacific region. Sharing relevant information on patient care, effective management, and productivity enhancement with network affiliates such as the Weill Cornell Medical College of Cornell University positions the Philippine hospital at the forefront of dynamic changes in the field of medical education, research and development.

Weill Medical College of Cornell University is among the top-ranked clinical and medical research centers in the United States. In addition to offering degrees in medicine, Cornell also has Ph.D. programs in biomedical research and education at the Weill Graduate School of Medical Sciences, and with neighboring Rockefeller University and the Sloan-Kettering Institute, has established a joint MD-PhD program for students to intensify their pursuit of Cornell's triple mission of education, research, and patient care.

The Medical College is divided into 20 academic departments: seven focus on the sciences underlying clinical medicine; and thirteen encompass the study, treatment, and prevention of human diseases, and maternity care. In addition to its affiliation with New York Presbyterian Healthcare System, Weill Medical College is affiliated with the Memorial Sloan-Kettering Cancer Center and the Hospital for Special Surgery. The Joan and Sanford I. Weill Medical College and Graduate School of Medical Sciences of Cornell University are accredited by the Liaison Committee on Medical Education of the American Medical Association and the Association of American Medical Colleges.